Week 2: VKH, part 3

Wow, and again it slipped to the end of the day. I WILL keep this resolution, goshdarnit.

#4: Utility of lumbar puncture in diagnosis of Vogt-Koyanagi-Harada disease

 Question the study is trying to answer: do we _really_ have to LP these people if they just have the characteristic ocular findings?

Study design: chart review of 116 patients with VKH

Results: only 10 patients were identified who had had LP; all 10 were Hispanic. 9 had had at least a headache, with varying other meningeal or auditory signs. 8 had abnormal CSF (6 with pleocytosis, 1 with “few WBC”, and 1″abnormal”, not specified further).


Basically, the authors don’t love the spinal tap based on it being somewhat nonspecific and  claiming the risks outweigh the benefits since the diagnosis can be essentially confirmed with ocular testing. I think this paper got cited a bunch elsewhere because I kept reading a statistic that “80%” had CSF pleocytosis, but 8/10 is not so very impressive, especially since it was such a small fraction of their VKH cohort.


1 Comment

Filed under Articles, Uncategorized

One response to “Week 2: VKH, part 3

  1. Pingback: Week 2: VKH, part 4 | Evidenced

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s